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KMID : 1009020160140010043
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Clinical Psychopharmacology and Neuroscience
2016 Volume.14 No. 1 p.43 ~ p.48
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Serum Levels of Growth Factors in Alcohol-dependent Patients according to Comorbid Depressive Symptoms
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Han Chang-Woo
Ahn Dong-Hyun
Hahm Woong
Nam Jung-Hyun
Park Yong-Chon
Lim Seul-Gi
Kim Dai-Jin
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Abstract
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Objective : This study aims to reveal the relationship of depression with growth factors such as brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF), and insulin-like growth factor-1 (IGF-1) in inpatients diagnosed with alcohol dependence, and to identify candidate growth factors as biological markers to indicate the comorbid of alcohol dependence and depression.
Methods : This study examined demographic factors in 45 alcohol-dependent patients. The ADS (Korean version of the Alcohol Dependence Scale) and BDI (Korean version of Beck’s Depression Inventory) were used. BDNF, NGF, and IGF-1 were measured through ELISA.
Results : The average drinking quantity and the ADS score were significantly more severe in alcohol-dependent patients with depression than in those without depression. Linearly comparing BDNF, NGF, and IGF-1 with BDI values, IGF-1 was the growth factor significantly correlated with BDI scores. BDI scores were significantly correlated with ADS scores. IGF-1 was significantly higher in alcohol-dependent patients with depression. Alcohol-dependent patients with depression had greater alcohol use and more severe ADS scores. BDNF and NGF showed no significant difference between alcohol-dependent patients with and without depression, but IGF-1 was significantly higher in those with than in those without depression.
Conclusion : IGF-1 was found to be associated with depression in alcohol-dependent patients, suggesting that IGF-1 in alcohol-dependent patients could be an important biomarker to indicate whether alcohol-dependence is accompanied by depression.
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KEYWORD
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Alcohol dependence, Depression, Growth factor, Insulin-like growth factor-1
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